Vitality is more than energy—it is biological coherence. It’s the ability of the body to adapt, respond, and recover with grace. At the core of vitality is harmonious immune function: a dynamic, interwoven system shaped by stress, nutrient status, and cellular communication.
Modern research increasingly supports what ancestral traditions have long practiced: that adaptogenic botanicals and essential micronutrients can help modulate immune activity, reduce inflammatory burden, and improve overall resilience—without overstimulation.
At IKKARI, we integrate these plant-based allies and minerals into daily rituals that are designed to nourish the nervous system, restore adrenal rhythm, and support immune balance at a cellular level. Here are the most well-studied, naturally derived ingredients that form the foundation of this support.
Rhodiola Root (Rhodiola rosea)
Rhodiola has been shown to reduce levels of cortisol and improve the body’s resistance to physical and emotional stress (R). In double-blind, placebo-controlled studies, rhodiola supplementation improved fatigue and cognitive performance in subjects under stress, suggesting immune-protective effects via HPA axis regulation (R). By lowering systemic stress, rhodiola may support immune regulation during both acute and chronic strain.
Ashwagandha Root (Withania somnifera)
Ashwagandha is one of the most studied adaptogens for stress modulation. Clinical trials have demonstrated its ability to significantly reduce cortisol levels and improve sleep quality, both critical to immune function (R). It also enhances natural killer (NK) cell activity—one of the body’s key front-line immune defenses (R).
Schisandra Berry (Schisandra chinensis)
Schisandra’s lignans possess immunomodulatory, liver protective, and antioxidant effects. Studies show its ability to enhance phagocytic activity and improve T-cell response while reducing oxidative stress markers (R). This broad-spectrum adaptogenic effect supports immune regulation during prolonged stress or detoxification demands.
Kakadu Plum (Terminalia ferdinandiana)
The most potent natural source of vitamin C. Kakadu plum contains up to 100 times more vitamin C than oranges, supporting the proliferation of lymphocytes and function of phagocytes. In vitro studies show it enhances immune cell signaling and reduces lipid peroxidation through its rich ellagic acid and gallic acid content (R). This makes it a potent antioxidant shield during periods of immune vulnerability.
Licorice Root (Glycyrrhiza glabra)
Licorice root isn’t just a traditional remedy—it has science-backed immune benefits too. In a clinical trial with COVID-19 patients, licorice supplements helped reduce inflammation markers like CRP and ALT, showing a calming effect on the immune system (R). Just another reason this ancient root is still so relevant today.
Holy Basil (Ocimum sanctum)
Holy basil, or Tulsi, is more than just a sacred plant—it’s a natural stress-buster. In a human study, people taking holy basil extract saw improvements in stress response and a drop in cortisol, our main stress hormone (R).
In vitro, it’s also been shown to help regulate inflammation by influencing pathways like COX-2 and NF-κB, which play a big role in chronic inflammatory conditions (R). That’s why it’s often called an adaptogen—it helps your body adapt and stay balanced under pressure.
Beetroot Powder (Beta vulgaris)
Beetroot is a powerhouse for circulation and cellular health. Thanks to its high nitrate content, it helps boost nitric oxide levels, which improves blood flow and nutrient delivery—even to immune tissues (R). It’s also packed with antioxidants like betalains and polyphenols, which help lower oxidative stress and support immune resilience—especially during physical or metabolic stress (R).
Immunity as a Daily Practice of Vitality
At IKKARI, we believe that immunity is not a seasonal concern, but a continuous flow—one best supported through daily rituals that nourish vitality through supporting the body’s stress response, nutrient profile, and cellular intelligence.
Where you can find some of these botanicals → Radiance, Vitality and Adrenal Support Tonics.